William Carvalho and Joao Cancelo were also on the scoresheet as the hosts wasted numerous opportunities to inflict more humiliation on the visitors, who suffered their biggest defeat since losing to Germany by the same scoreline in 2008.
Portugal have four points from their opening two Group A2 matches and are ahead of second-place Czech Republic on goal-difference. Switzerland are on zero after back-to-back losses and are now winless in their last four encounters since they qualified for the World Cup in Qatar.
Carvalho opened the scoring when he reacted quickest to the loose ball when Ronaldo’s free-kick was parried, before the latter bagged a quickfire brace to extend his record tally of international goals to 117.
Ronaldo should have had a hat-trick when he wasted two excellent opportunities before halftime, the first a barely believable miss from six yards, but it was left to Cancelo to score the fourth for Portugal in the second half.
Portugal host Czech Republic in their next fixture on Thursday, while Switzerland entertain Spain in Geneva on the same evening.
Photo Portugal’s Cristiano Ronaldo celebrates after scoring the 2-0 lead during the UEFA Nations League soccer match between Portugal and Switzerland in Lisbon, Portugal, 05 June 2022. EPA-EFE/LAURENT GILLIERON