Holders France got their World Cup qualifying campaign off to a disappointing start with a 1-1 draw at home to Ukraine on Wednesday while Turkey pulled off an impressive 4-2 win at home to the Netherlands, powered by a Burak Yilmaz hat-trick.
Croatia, 2018 runners-up, slumped to a shock 1-0 defeat away to Slovenia, while Belgium continued their remarkable run in qualifiers by coming from behind to beat Wales 3-1 at home.
Ireland ended a seven-game drought by scoring twice away to Serbia but still got beaten 3-2, while Czech Republic routed Estonia 6-2 in the biggest win of the night and Portugal scraped past minnows Azerbaijan 1-0 courtesy of an own goal.
Antoine Griezmann put France in charge of their Group D game against Ukraine to move level with David Trezeguet as his country’s fourth all-time top scorer.
Ukraine, who were hammered 7-1 by France in a UEFA Nations League game last October, levelled in the second half through a Presnel Kimpembe own goal.
The visitors held on for the draw despite having no shots on target, although Kimpembe spurned a chance to grab a last-gasp winner and make amends for his error.